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  • Titre:transforming matters

    La description :-- home …basic bits and bolts of chemistry… practical isolation of the (1 r ,2 r )-enantiomer from a racemic cis/trans mixture of 2-methyl-1-cyclohexanamine posted by daveb on octobre 17, 2017 furegat...

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-- home …basic bits and bolts of chemistry… practical isolation of the (1 r ,2 r )-enantiomer from a racemic cis/trans mixture of 2-methyl-1-cyclohexanamine posted by daveb on octobre 17, 2017 furegati, nocito, org. process res. dev. 2017 [ 10.1021/acs.oprd.7b00263 ] posted in industrial scale meta no comments , permalink , rss an improved synthesis of amantadine hydrochloride posted by daveb on octobre 16, 2017 vu, nguyen, le, phan, org. process res. dev. 2017 [ 10.1021/acs.oprd.7b00242 ] posted in industrial scale meta no comments , permalink , rss a boron protecting group strategy for 1,2-azaborines posted by daveb on octobre 11, 2017 baggett, liu, j. am. chem. soc. 2017 [ 10.1021/jacs.7b09491 ] posted in boron chemistry , protecting groups , for hydroxyls meta no comments , permalink , rss laser-initiated radical trifluoromethylation of peptides and proteins: application to mass-spectrometry-based protein footprinting posted by daveb on octobre 06, 2017 cheng, zhang, cui, gross, angew. chem. int. ed. 2017 [ 10.1002/anie.201706697 ] posted in fluorine chemistry , medchem - bioisosterism , peptides , photochemistry meta no comments , permalink , rss esterification of carboxylic acids with difluoromethyl diazomethane and interrupted esterification with trifluoromethyl diazomethane: a fluorine effect posted by daveb on octobre 05, 2017 peng, zhang, zhang, hu, org. lett. 2017 [ 10.1021/acs.orglett.7b02866 ] posted in flow chemistry , fluorine chemistry meta no comments , permalink , rss 1-trifluoromethylisoquinolines from α-benzylated tosylmethyl isocyanide derivatives in a modular approach posted by daveb on octobre 04, 2017 wang, studer, org. lett. 2017 [ 10.1021/acs.orglett.7b02882 ] posted in fluorine chemistry , heterocycles meta no comments , permalink , rss remote, late-stage oxidation of aliphatic c–h bonds in amide-containing molecules posted by daveb on octobre 04, 2017 nanjo, de lucca, white, j. am. chem. soc. 2017 [ 10.1021/jacs.7b07665 ] posted in oxidation meta no comments , permalink , rss ligand-promoted palladium-catalyzed aerobic oxidation reactions posted by daveb on octobre 04, 2017 wang, weinstein, white, stahl, chem. rev. 2017 [ 10.1021/acs.chemrev.7b00334 ] posted in oxidation meta no comments , permalink , rss nickel(ii)-catalyzed site-selective c–h bond trifluoromethylation of arylamine in water through a coordinating activation strategy posted by daveb on octobre 02, 2017 xu, qiao, shen, chai, shen, zhang, org. lett. 2017 [ 10.1021/acs.orglett.7b02823 ] posted in ch-activation , fluorine chemistry meta no comments , permalink , rss oxidative synthesis of benzimidazoles, quinoxalines, and benzoxazoles from primary amines by ortho -quinone catalysis posted by daveb on octobre 02, 2017 zhang, qin, zhang, luo, org. lett. 2017 [ 10.1021/acs.orglett.7b02786 ] posted in heterocycles , oxidation meta no comments , permalink , rss metal- and solvent-free approach to diversely substituted picolinates via domino reaction of cyclic sulfamidate imines with β,γ-unsaturated α-ketocarbonyls posted by daveb on octobre 02, 2017 biswas, majee, guin, samanta, j. org. chem. 2017 [ 10.1021/acs.joc.7b01792 ] posted in heterocycles meta no comments , permalink , rss a practical and scalable system for heteroaryl amino acid synthesis posted by daveb on octobre 02, 2017 aycock, vogt, jui, chem. sci. 2017 [ 10.1039/c7sc03612d ] posted in heterocycles , photochemistry , reduction , transition metal catalysis meta no comments , permalink , rss design, synthesis, and application of polymer-supported silicon-transfer agents for cross-coupling reactions with organolithium reagents posted by daveb on octobre 02, 2017 nguyen, o’brien, smith, j. org. chem. 2017 [ 10.1021/acs.joc.7b02004 ] posted in organometallics meta no comments , permalink , rss difluorocarbene for dehydroxytrifluoromethylthiolation of alcohols posted by daveb on septembre 29, 2017 luo, zhang, lin, xiao, j. org. chem. 2017 [ 10.1021/acs.joc.7b01701 ] posted in fluorine chemistry meta no comments , permalink , rss learning medicinal chemistry absorption, distribution, metabolism, excretion, and toxicity (admet) rules from cross-company matched molecular pairs analysis (mmpa) posted by daveb on septembre 28, 2017 kramer, ting, zheng, hert, schindler, stahl, robb, crawford, blaney, montague, leach, dossetter, griffen, j. med. chem. 2017 [ 10.1021/acs.jmedchem.7b00935 ] posted in medchem - bioisosterism meta no comments , permalink , rss manganese-based photoredox catalysis for c-h alkylation of heteroarenes: applications and mechanistic studies posted by daveb on septembre 28, 2017 oderinde, nuhant, genovino, juneau, gagné, allais, chinigo, choi, sach, bernier, bundesmann, khunte, frenette, fadeyi, fobian, angew. chem. int. ed. 2017 [ 10.1002/anie.201707958 ] posted in photochemistry , radicals chemistry meta no comments , permalink , rss photoredox enables the construction of 1,1-difluoroalkene carbonyl mimics posted by daveb on septembre 28, 2017 molander, lang, wiles, kelly, angew. chem. int. ed. 2017 [ 10.1002/anie.201709487 ] posted in fluorine chemistry , medchem - bioisosterism , photochemistry , radicals chemistry meta no comments , permalink , rss beyond the rule of 5: lessons learned from abbvie’s drugs and compound collection posted by daveb on septembre 27, 2017 degoey, chen, cox, wendt, j. med. chem. 2017 [ 10.1021/acs.jmedchem.7b00717 ] posted in medchem - bioisosterism , physical chemistry meta no comments , permalink , rss discovery of a potent and specific m. tuberculosis leucyl-trna synthetase inhibitor: ( s )-3-(aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[ c ][1,2]oxaborol-1(3 h )-ol (gsk656) posted by daveb on septembre 27, 2017 li, hernandez, rock, choi, mak, mohan, mao, zhou, easom, plattner, zou, pérez-herrán, giordano, mendoza-losana, alemparte, rullas, angulo-barturen, crouch, ortega, barros, alley, j. med. chem. 2017 [ 10.1021/acs.jmedchem.7b00631 ] posted in boron chemistry , medchem - bioisosterism meta no comments , permalink , rss synthesis of bicyclic isothiazoles through an intramolecular rhodium-catalyzed transannulation of cyanothiadiazoles posted by daveb on septembre 25, 2017 seo, kim, kim, baek, um, lee, j. org. chem. 2017 , 82(19), 10574-10582 [ 10.1021/acs.joc.7b02077 ] posted in heterocycles meta no comments , permalink , rss synthetic nat- or ent-steroids in as few as five chemical steps from epichlorohydrin posted by daveb on septembre 25, 2017 kim, du, eastman, hughes, micalizio, nat. chem. 2017 [ 10.1038/nchem.2865 ] posted in medchem - bioisosterism meta no comments , permalink , rss an aminocatalyzed michael addition/iron-mediated decarboxylative cyclization sequence for the preparation of 2,3,4,6-tetrasubstituted pyridines: scope and mechanistic insights posted by daveb on septembre 22, 2017 stivanin, duarte, sartori, capreti, angolini, jurberg, j. org. chem. 2017 , 82(19), 10319-10330 [ 10.1021/acs.joc.7b01789 ] posted in heterocycles meta no comments , permalink , rss reaction dynamics: the view from a transition state posted by daveb on septembre 22, 2017 continetti, nat. chem. 2017 , 9(10), 931-932 [ 10.1038/nchem.2868 ] posted in theoretical chemistry & mechanism meta no comments , permalink , rss modular access to triarylethylene units from arylvinyl mida boronates using a regioselective heck coupling posted by daveb on septembre 22, 2017 khanizeman, barde, bates, guérinot, cossy, org. lett. 2017 , 19(19), 5046-5049 [ 10.1021/acs.orglett.7b02218 ] posted in boron chemistry , heck coupling , transition metal catalysis meta no comments , permalink , rss joining forces: the chemical biology–medicinal chemistry continuum posted by daveb on septembre 21, 2017 plowright, ottmann, arkin, auberson, timmerman, waldmann, cell chemical biology 2017 , 24(9), 1058-1065 [ 10.1016/j.chembiol.2017.05.019 ] posted in medchem - bioisosterism meta no comments , permalink , rss intermolecular radical addition to carbonyls enabled by visible light photo

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